Differentiating glioblastoma multiforme from cerebral lymphoma: application of advanced texture analysis of quantitative apparent diffusion coefficients

Glioblastoma multiforme (GBM) and primary central nervous system lymphoma (PCNSL) are two known brain malignancies. Overlapping imaging features of hypercellular GBM and PCNSL tumours makes it hard to separate them apart. GBMs are expected to be more heterogenous than PCNSLs, since they harbour infiltrating cells around the tumour bulk which is less common in PCNSL. Conventional MRI may not be able to distinguish this heterogeneity. The authors differentiate GBM from PCNSL with texture features derived from ADC maps in two selected ROIs. This is a promising technique in clinical decisions and treatment planning for brain tumours.

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Author: Ms. Mahsa Talebi

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