05
May

0

MDCT-QCT, QUS, and DXA in healthy adults: An intermodality comparison

Abstract Background: Cortical deceleration is the main reason for bone loss at peripheral sites. It was suggested that when peripheral bones were assessed for osteoporosis, management and therapy can be administered early. The main aim of this study was to assess the relationships between the central and peripheral measurements at different skeleton bone sites (spine, […]

05
May

0

A hybrid (iron–fat–water) phantom for liver iron overload quantification in the presence of contaminating fat using magnetic resonance imaging

Abstract OBJECTIVE: Assessment of iron content in the liver is crucial for diagnosis/treatment of iron-overload diseases. Nonetheless, T2*-based methods become challenging when fat and iron are simultaneously present. This study proposes a phantom design concomitantly containing various concentrations of iron and fat suitable for devising accurate simultaneous T2* and fat quantification technique. MATERIALS AND METHODS: […]

05
May

0

Differentiation of benign from malignant adnexal masses by dynamic contrast-enhanced MRI (DCE-MRI): Quantitative and semi-quantitative analysis at 3-tesla MRI

Abstract BACKGROUND: To evaluate the utility of the pharmacokinetic modeling derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in differentiating benign from malignant adnexal masses. METHODS: A total of 43 patients with 49 complex adnexal masses (27 benign, 3 borderline, and 19 malignant lesions) underwent preoperative DCE-MRI examinations on a 3 Tesla MRI. Using extended […]

05
May

0

Quantification of ASL Perfusion MRI in MCI Patients Using Single-Post Labeling Delay Model-Fitting Approach

Abstract Purpose: Neuroimaging techniques hold many promises to detect Alzheimer Disease (AD) at early stages before clinical symptoms fully develop, suggesting decreased regional Cerebral Blood Flow (CBF). Perfusion deficiencies are present from very early clinical phases of AD, i.e. Mild Cognitive Impairment (MCI) and persist well into the latest stages, demonstrating a pattern of increased […]

05
May

0

Diffusion MRI for Assessment of Bone Quality; A Review of Findings in Healthy Aging and Osteoporosis

Abstract Diffusion MRI (dMRI) is a growing imaging technique with the potential to provide biomarkers of tissue variation, such as cellular density, tissue anisotropy, and microvascular perfusion. However, the role of dMRI in characterizing different aspects of bone quality, especially in aging and osteoporosis, has not yet been fully established, particularly in clinical applications. The […]

05
May

0

Analyzing brain structural differences associated with categories of blood pressure in adults using empirical kernel mapping-based kernel ELM+

Abstract Background: Hypertension increases the risk of angiocardiopathy and cognitive disorder. Blood pressure has four categories: normal, elevated, hypertension stage 1 and hypertension stage 2. The quantitative analysis of hypertension helps determine disease status, prognosis assessment, guidance and management, but is not well studied in the framework of machine learning. Methods: We proposed empirical kernel […]

05
May

0

PEGylation of graphene/iron oxide nanocomposite: assessment of release of doxorubicin, magnetically targeted drug delivery and photothermal therapy

Abstract Scientists have recommended to investigate graphene and graphene base compounds for their potential uses in a variety of fields, such as biomedicine and drug release. A PEGylated and functionalized magnetic graphene oxide (MG–NH2–PEG) complex was used herein as a nanocarrier of Doxorubicin, a cancer chemotherapy drug. First, graphene oxide was synthesized by modified Hummer’s […]

28
Apr

0
 ADC-Derived Spatial Features Can Accurately Classify Adnexal Lesions

ADC-Derived Spatial Features Can Accurately Classify Adnexal Lesions

Abstract Background: The role of quantitative apparent diffusion coefficient (ADC) maps in differentiating adnexal masses is unresolved. Objective: To propose an objective diagnostic method devised based on spatial features for predicting benignity/malignancy of adnexal masses in ADC maps. Results: The selected feature subspace consisting of RLM features differentiated benign from malignant adnexal masses with a […]

28
Apr

0
Heterogeneity analysis of difusion‑weighted MRI for prediction and assessment of microstructural changes early after one cycle of induction chemotherapy in nasopharyngeal cancer patients

Heterogeneity analysis of difusion‑weighted MRI for prediction and assessment of microstructural changes early after one cycle of induction chemotherapy in nasopharyngeal cancer patients

Abstract Purpose To evaluate whether the pretreatment apparent difusion coefcient (ADC) heterogeneity parameters and their alterations, after one cycle of induction chemotherapy, can be used as reliable markers of treatment response to induction chemotherapy in patients with nasopharyngeal cancer. Materials and methods Ten patients were recruited and received induction chemotherapy (IC). Difusion-weighted imaging was performed […]

01
May

0
Spatiotemporal features of DCE-MRI for breast cancer diagnosis

Spatiotemporal features of DCE-MRI for breast cancer diagnosis

Abstract Breast cancer is a major cause of mortality among women if not treated in early stages. Previous works developed non-invasive diagnosis methods using imaging data, focusing on specific sets of features that can be called spatial features or temporal features. However, limited set of features carry limited information, requiring complex classification methods to diagnose […]

01
May

0
A One-Step Biomarker Quantification Methodology for DCE-MRI of Adnexal Masses

A One-Step Biomarker Quantification Methodology for DCE-MRI of Adnexal Masses: Capturing Kinetic Pattern from Early to Late Enhancement

Abstract Objective: To develop a one-step quantification approach that accounts for joint preprocessing and quantification of wholerange kinetics (early and late-phase washout) of dynamic contrast-enhanced (DCE) MRI of indeterminate adnexal masses. Results: The results revealed that P2, representing the enhancement amplitude, is significantly higher, and P5, indicating the terminal phase, is generally negative in malignant […]

01
May

0
Characterization of Active and Infiltrative Tumorous Subregions From Normal Tissue in Brain Gliomas Using Multiparametric MRI

Characterization of Active and Infiltrative Tumorous Subregions From Normal Tissue in Brain Gliomas Using Multiparametric MRI

Abstract Objective: To explore the complementary and competitive roles of a variety of conventional and quantitative MRI methods for distinguishing subregions of brain gliomas. Results: After exclusion of 17 tissue specimens, 34 samples (AT 5 6, IE 5 20, and NT 5 8) were considered for analysis. Highest accuracies and statistically significant differences for discrimination […]

01
May

0

Malignancy probability map as a novel imaging biomarker to predict malignancy distribution: employing MRS in GBM patients

Abstract The main aim of this study was to propose a new statistical method for evaluation of spatial malignancy distribution within Magnetic Resonance Spectroscopy (MRS) grid in Glioblastoma Multiforme patients. Voxels with different malignancy probabilities were presented as a novel MRS-based Malignancy Probability Map (MPM). For this purpose, a predictive probability-based clustering approach was developed, […]

01
May

0

Findings of DTI-p maps in comparison with T2/T2-FLAIR to assess postoperative hyper-signal abnormal regions in patients with glioblastoma

Abstract Objective: The aim of this study was to compare diffusion tensor imaging (DTI) isotropic map (p-map) with current radiographically (T2/T2-FLAIR) methods based on abnormal hyper-signal size and location of glioblastoma tumor using a semi-automatic approach. Results: Area of abnormality in the p-map was smaller than the corresponding areas in the T2 and T2-FLAIR images […]

01
May

0

Accurate classification of brain gliomas by discriminate dictionary learning based on projective dictionary pair learning of proton magnetic resonance spectra

Abstract Proton magnetic resonance spectroscopy is a powerful noninvasive technique that complements the structural images of conventional magnetic resonance imaging, which aids biomedical and clinical researches, by identifying and visualizing the compositions of various metabolites within the tissues of interest. However, accurate classification of proton magnetic resonance spectroscopy is still a challenging issue in clinics […]

01
May

0

Single STE-MR Acquisition in MR-based Attenuation Correction of Brain PET Imaging Employing a Fully Automated and Reproducible Level-set Segmentation Approach

Abstract Objective: The aim of this study is to introduce a fully automatic and reproducible short echo-time (STE) magnetic resonance imaging (MRI) segmentation approach for MR-based attenuation correction of positron emission tomography (PET) data in head region. Results: The proposed segmentation method returned accuracy and specificity values of over 90 % for cortical bone, air, […]

01
May

0
Quantifying Human Cortical Bone Bound and Free Water in vivo from Ultrashort Echo-Time MRI

Quantifying Human Cortical Bone Bound and Free Water in vivo from Ultrashort Echo-Time MRI: A Model-Based Approach

Abstract Objective: To quantify free and bound water components of cortical bone with a model-based numeric approach with use of ultrashort echo time (UTE) magnetic resonance (MR) imaging in vivo in order to introduce a new predictor for age related deterioration of cortical bone structure. Results: The mean free water concentration, bound water concentration, free […]

01
May

0

Semi-Quantitative Dynamic Contrast Enhanced MRI for Accurate Classification of Complex Adnexal Masses

Abstract Objective: To identify the best dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) descriptive parameters in predicting malignancy of complex ovarian masses, and develop an optimal decision tree for accurate classification of benign and malignant complex ovarian masses. Results: TTP (P 5 6.15E-8) and WIR (P 5 5.65E-5) parameters induced the highest sensitivity (89% for […]

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