Characterization of Active and Infiltrative Tumorous Subregions From Normal Tissue in Brain Gliomas Using Multiparametric MRI





To explore the complementary and competitive roles of a variety of conventional and quantitative MRI methods for distinguishing subregions of brain gliomas.


After exclusion of 17 tissue specimens, 34 samples (AT 5 6, IE 5 20, and NT 5 8) were considered for analysis. Highest accuracies and statistically significant differences for discrimination of IE from NT and AT from NT were observed for diffusion-based parameters (AUCs >90%), and the perfusion-derived parameter as the most accurate feature in distinguishing IE from AT. A combination of “CBV, MD, T2_ISO, FLAIR” parameters showed high diagnostic performance for identification of the three subregions (AUC 90%).


Infiltrative Tumorous Subregions, Gliomas, Multiparametric MRI

Anahita Fathi Kazerooni, Mahnaz Nabil, Mehdi Zeinali Zadeh, Kavous Firouznia, Farid Azmoudeh Ardalan, Alejandro F. Frangi, Christos Davatzikos and Hamidreza Saligheh Rad .

Journal of Magnetic Resonance Imaging
Scroll to Top