1H-MRS metabolite’s ratios show temporal alternation in temporal lobe seizure: Comparison between interictal and postictal phases





To determine 1H-MRSI metabolites changes in interictal and postictal phases of patients suffering from mesial temporal lobe epilepsy with hippocampal sclerosis and lateralization of seizure foci.

Materials and Methods:

MR spectroscopic imaging was performed in 5 adult patients with refractory temporal lobe epilepsy interictally and immediately after the seizure and in 4 adult control subjects. All patients underwent MR imaging and VideoEEG Monitoring.


The results showed statistically significant decreases in N-acetylaspartate/Creatine, Nacetylaspartate/Choline and N-acetylaspartate/(creatine + choline) immediately after ictus in ipsilateral hippocampus as compared with control data and contralateral hippocampus of patients while no statistically significant difference was presented in interictal phase.


The present study clearly indicates 1H-MRS abnormalities following an ictus of temporal lobe
epilepsy with metabolite recovery in interictal phase. This finding suggests postictal 1H-MRS as a possible usefultoolto assistin lateralizing and localizing of seizure foci in epileptic patients with structural lesions.


Temporal lobe epilepsy, Proton MR spectroscopy imaging, Seizure, Metabolites ratio .

Fatemeh Fadaie, Neda Mohammadi Mobarakeh, Sayed Sohrab Hashemi Fesharaki, Mohammad Hossein Harirchian, Homayoun Hadizadeh Kharazi, Hamidreza Saligheh Rad, Jafar Mehvari Habibabadi .

Epilepsy research
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