1H-MRS metabolite’s ratios show temporal alternation in temporal lobe seizure: Comparison between interictal and postictal phases


Objective: To determine 1H-MRSI metabolites changes in interictal and postictal phases of patients suffering from mesial temporal lobe epilepsy with hippocampal sclerosis and lateralization of seizure foci.
Materials and Methods: MR spectroscopic imaging was performed in 5 adult patients with refractory temporal lobe epilepsy interictally and immediately after the seizure and in 4 adult control subjects. All patients underwent MR imaging and VideoEEG Monitoring.
Results: The results showed statistically significant decreases in N-acetylaspartate/Creatine, Nacetylaspartate/Choline and N-acetylaspartate/(creatine + choline) immediately after ictus in ipsilateral hippocampus as compared with control data and contralateral hippocampus of patients while no statistically significant difference was presented in interictal phase.
Conclusion: The present study clearly indicates 1H-MRS abnormalities following an ictus of temporal lobe
epilepsy with metabolite recovery in interictal phase. This finding suggests postictal 1H-MRS as a possible usefultoolto assistin lateralizing and localizing of seizure foci in epileptic patients with structural lesions.


Temporal lobe epilepsy, Proton MR spectroscopy imaging, Seizure, Metabolites ratio .

Fatemeh Fadaie, Neda Mohammadi Mobarakeh, Sayed Sohrab Hashemi Fesharaki, Mohammad Hossein Harirchian, Homayoun Hadizadeh Kharazi, Hamidreza Saligheh Rad, Jafar Mehvari Habibabadi .

Epilepsy research
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