The Laboratory for Advanced MR Imaging and Spectroscopy (LAMIS) is dedicated to the design and development of next-generation MRI pulse sequences, integrated with comprehensive quality control and assurance systems for both acquisition hardware and analysis software. The LAMIS team pioneers innovative methodologies to create novel contrast mechanisms, enabling the generation of high-accuracy, pathology-specific, and hardware-driven biomarkers for disease diagnosis and treatment planning. This paradigm-shifting approach encompasses:
- Spin manipulation and simulation platforms for contrast optimization
- Custom pulse sequence design tailored to specific diagnostic needs
- On-demand hardware development to support advanced acquisition strategies
- Application-specific reconstruction algorithms for enhanced image fidelity
Integrated quality control workflows to ensure reproducibility and clinical reliability
Spin Dynamics
- Modeling and understanding MR signal generation and acquisition mechanisms
- Analysis across various pulse sequences and imaging protocols
MRI Simulation
- Development of a high-fidelity MRI simulator platform
- Realistic image generation using Bloch equation modeling
- Simulation of k-space sampling, contrast, artifacts, and noise
Pulse Sequence Development
- Design of next-generation MRI pulse sequences
- Creation of novel contrast mechanisms
- Development of pathology-specific and hardware-driven biomarkers
RF Engineering
- Design and fabrication of MRI RF coils
- Support for multi-nuclei imaging applications
Quality Control and Assurance (QC/QA)
- Development of QC/QA workflows for advanced acquisition paradigms
- Integration with MRI software analytics for clinical reliability
Contrast Agent Development
- Engineering of next-generation MRI contrast agents
- Support for early detection and high-throughput treatment
- Applications in personalized medicine
Accurate Quantification of Iron Using MRI
- Development of MRI-based techniques for precise iron quantification in biological tissues
- Design and fabrication of calibration and validation phantoms to ensure measurement accuracy and reproducibility
Magnetic Resonance Fingerprinting (MRF) Simulation Platform
- Implementation of a computer-based simulation environment for MRF
- Modeling of tissue-specific signal evolutions and dictionary-based reconstruction for quantitative imaging
Quantification of Metabolite Concentrations in ¹H-MRS of the Brain
- Advanced spectral analysis techniques for accurate metabolite profiling
- Application to neurological disorders and brain metabolism studies
Design and Development of Experimental and Research NMR Systems
- Engineering of custom NMR setups for non-clinical and exploratory applications
- Integration of hardware and software components for flexible pulse programming and signal acquisition