The Quantitative MR Imaging and Spectroscopy Group (QMISG)
The Quantitative MR Imaging and Spectroscopy Group (QMISG) is a multi-disciplinary magnetic resonance quantification research group established in 2012 at the Research Center for Molecular and Cellular Imaging (RCMCI). QMISG gathers interested researchers, scientists, and physicians who share a common concern in utilizing and developing novel imaging and computational technologies to provide a framework for accurate diagnosis of human diseases and monitoring the anatomical and physiological changes resulting from pathologies or in response to the planned treatment.
At QMISG, we believe that the future of MRI/S will be premised from blending basic science with advanced image formation and quantification technologies to investigate biomarkers of disease progression. Specifically, our mission is to:
- To leverage the existing expertise in engineering, sciences, and veterinary medicine to improve healthcare through advanced magnetic resonance imaging,
- Quantification and development of imaging protocols and software for various MRS/MRI applications,
- Treatment planning and decision making in various applications, e.g. cancer therapy,
- Analysis and quantification of MR images for treatment response follow-up,
- In-vitro and in-vivo image processing and analysis.
The activities of QMISG are concentrated on (but not dedicated to) cortical bone quantification using Short-TE MRI pulse sequences in various applications, e.g. quantification of Bone Water Concentration (BWC) or PET-MR attenuation map generation, analysis, quantification and processing of MRS signals in different diseases, such as brain tumors, multiple sclerosis, etc., analysis, quantification and method development in MR perfusion and diffusion studies (DSC-, DCE- MRI, and DTI) in brain and abdominal organs, analysis and quantification of whole-body MR images for treatment response follow-up, e.g. in metastatic bone marrow cancers, and protocol and Software development for various MRS/MRI applications.
Research Priorities of QMISG
Magnetic Resonance Imaging/Spectroscopy for Oncological Applications Developing pre-clinical imaging protocols for treatment and surgical planning, prediction of tumor response to therapy, treatment response follow-up, and monitoring tumor progression in diverse clinical applications such as brain tumors, breast tumors, whole-body metastatic cancers in bone marrow or lymphoma, ovarian mass, etc. Biomarker development Developing advanced MR imaging techniques for identification of specific biomarkers, endpoints of in-vivo progression, and response to therapy in several diseases, such as cortical bone quantification in Osteoporosis. Applications of Neuroimaging Developing advanced anatomical and physiological MR imaging and spectroscopy quantification techniques for diagnosing neuro-pathologies such as multiple sclerosis, various brain tumors, epilepsy, stroke, etc.